Like with Clear, there's no right moment to cleanse; the most common condition is when your opponent has stacked alot of debuffs on you, this can either be recoil, afterburn, or residual damage. Sometimes, however, people use cleanse to get rid of annoying effects(bloodline seal, recoil) when they are looking to hit for a large amount of damage.

Cleansable Tags | TheNinja-RPG

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What cleanse can remove

Cleanse removes harmful effects from the target (usually yourself). It does not restore health on its own and it does not remove shields or buffs — that is clear.

Cleanseable Tags

Cleanse removes negative effects currently active on a player. The following effects can be removed by Cleanse:

Afterburn
Buff Prevent
Decrease Damage Given
Decrease Heal
Decrease Stat
Decrease Max Pools
Disarm
Drain
Elemental Seal
Heal Prevent
Increase Damage Taken
Increase Pool Cost
Increase Cooldown
Move Prevent
Poison
Recoil
Seal
Summon Prevent
Time Compression
Wound

If one of these negative effects is active when a Cleanse effect is successfully used, it can be removed from the affected player.

Frequently asked questions

When to Cleanse: Like with Clear, there's no right moment to cleanse; the most common condition is when your opponent has stacked alot of debuffs on you, this can either be recoil, afterburn, or residual damage. Sometimes, however, people use cleanse to get rid of annoying effects(bloodline seal, recoil) when they are looking to hit for a large amount of damage.